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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

Kevin Y Xu1, Shenhong Wu2

  • 1Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY USA.

Biomarker Research
|March 4, 2015
PubMed

Insights

New targeted therapies and immunotherapies show promise for advanced renal-cell carcinoma (RCC). Recent studies translate tumor biology insights into improved outcomes for clear-cell and non-clear cell metastatic RCC patients.

Area of Science:

  • Oncology
  • Molecular Pathology

Background:

  • Advances in understanding renal-cell carcinoma (RCC) molecular pathology.
  • Emergence of targeted therapies based on tumor biology.

Purpose of the Study:

  • Review new targeted treatments and immunotherapies for metastatic RCC.
  • Discuss developments presented at the 2014 American Society of Clinical Oncology (ASCO) annual conference.

Main Methods:

  • Literature review of recent studies on RCC treatments.
  • Focus on anti-VGF agents and PD-1 inhibitors.

Main Results:

  • Several new studies demonstrate improved outcomes in advanced RCC.
  • Emerging treatments show considerable promise for RCC patients.

Conclusions:

  • Targeted therapies and immunotherapies are transforming advanced RCC treatment.
  • Continued research into novel agents like anti-VGF and PD-1 inhibitors is crucial.
Keywords:
Clear cellNon-clear cellPD-1Renal cell carcinomaTyrosine kinase inhibitor

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