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Anaplastic large cell lymphoma associated with breast implants.

Shalini Ravi-Kumar1, Omid Sanaei2, Mohammad Vasef1

  • 1University of New Mexico Cancer Center, Albuquerque, NM, USA.

World Journal of Plastic Surgery
|March 4, 2015
PubMed
Summary

A woman with breast implants developed poor wound healing and lymph node swelling. Diagnosis revealed anaplastic large cell lymphoma (ALCL) associated with her breast implants.

Keywords:
AnaplasticBreastImplantLarge Cell Lymphoma

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Area of Science:

  • Oncology
  • Pathology
  • Plastic Surgery

Background:

  • Breast augmentation is a common cosmetic procedure.
  • Complications can include poor wound healing and atypical tissue reactions.
  • Lymphoid infiltrates near implants warrant thorough investigation.

Observation:

  • A 42-year-old woman presented with poor surgical site healing post-bilateral breast augmentation.
  • Tissue and fluid analysis revealed atypical lymphoid infiltrate.
  • Axillary lymphadenopathy developed, necessitating further investigation.

Findings:

  • Excisional biopsy and flow cytometry were performed.
  • A nodular area in the breast specimen confirmed ALK-negative anaplastic large cell lymphoma (ALCL).
  • The patient underwent implant removal and mastectomy due to persistent poor healing.

Implications:

  • This case highlights a rare association between breast implants and ALK-negative ALCL.
  • Early recognition of atypical lymphoid responses is crucial in patients with breast implants.
  • Further research is needed to understand the pathogenesis and management of implant-associated lymphomas.