Renal effects of targeted anticancer therapies

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Camillo Porta1, Laura Cosmai2, Maurizio Gallieni3

  • 1Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, Piazzale C. Golgi 19, 27100 Pavia, Italy.

Nature Reviews. Nephrology
|March 4, 2015
PubMed

Insights

Novel targeted anticancer agents improve cancer prognosis but can harm kidneys. Understanding these renal toxic effects is crucial for safe treatment and preserving kidney function in cancer patients.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Novel targeted anticancer agents improve cancer patient outcomes.
  • These therapies are linked to increased risks of kidney toxicity.
  • Pre-existing kidney impairment in cancer patients complicates management.

Purpose of the Study:

  • To review the renal safety profiles of novel targeted anticancer agents.
  • To discuss modifications needed for managing patients undergoing these therapies.
  • To highlight the importance of onconephrology.

Main Methods:

  • Comprehensive literature review of targeted anticancer agents and their renal effects.
  • Analysis of pharmacokinetic and pharmacodynamic properties relevant to kidney function.
  • Discussion of management strategies for onconephrologic care.

Main Results:

  • Novel anticancer agents present unique and often poorly characterized renal toxicities.
  • Dose adjustments and treatment modifications may be necessary based on renal function.
  • Understanding drug metabolism and excretion is key to mitigating kidney damage.

Conclusions:

  • A thorough understanding of renal safety is essential for optimizing cancer treatment.
  • Onconephrology as a subspecialty is needed to address the complexities of cancer and kidney disease.
  • Proactive management can help preserve kidney function in patients receiving targeted therapies.

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