Bone regenerative potential of modified biphasic graft materials
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Updated: Apr 16, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Rehan Khan1, Lukasz Witek, Matthew Breit
1*Research Associate, Department of Biomedical Engineering, Polytechnic Institute of New York University, Brooklyn, NY. †Doctoral Candidate, School of Chemical Engineering, Oklahoma State University, Stillwater, OK. ‡Researcher, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY. §Researcher, Department of Biomedical Engineering, City College of New York, New York, NY. ‖Adjunct Professor, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY. ¶Senior Scientist, Department of Epidemiology and Health Promotion, New York University, New York, NY. #Associate Professor, Department of Prosthodontics, Faculty of Odontology, Malmo University, Malmö, Sweden. **Associate Professor, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY.
Purpose:
To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials.
Materials And Methods:
The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss™, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis.
Results:
Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks.
Conclusion:
Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.
