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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

897
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
897
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Algorithm for managing severe ulcerative colitis.

Vineet Ahuja, Ajay Kumar, Rakesh Kochhar

    Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
    |March 5, 2015
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    Summary
    This summary is machine-generated.

    Acute severe ulcerative colitis requires hospitalization and close monitoring. This article outlines a time-bound algorithm for managing severe ulcerative colitis, including steroid therapy and rescue options like cyclosporine and infliximab.

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    Area of Science:

    • Gastroenterology
    • Internal Medicine
    • Clinical Management

    Background:

    • Acute severe ulcerative colitis (ASUC) is a medical emergency necessitating hospitalization.
    • Truelove and Witt's criteria define ASUC, guiding initial management.
    • Standard care involves intensive monitoring and intravenous corticosteroids.

    Purpose of the Study:

    • To provide a time-bound, step-up algorithm for managing acute severe ulcerative colitis.
    • To guide clinicians in assessing steroid response and initiating rescue therapies.

    Main Methods:

    • Clinical monitoring of vital signs, stool frequency, and electrolytes.
    • Daily abdominal examinations.
    • Assessment of corticosteroid response by day 3 of admission.

    Main Results:

    • Approximately two-thirds of patients respond to intravenous corticosteroids.
    • Partial or non-responders require consideration for alternative medical therapy or surgery.

    Conclusions:

    • A structured, time-bound approach is crucial for effective ASUC management.
    • Early identification of non-responders allows for timely escalation to rescue therapies (cyclosporine, infliximab) or surgical intervention.