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Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism
C Wynants1, D Tourwe, W Kazmierski
1Laboratory of Organic Chemistry, Vrije Universiteit Brussel, Belgium.
European Journal of Biochemistry
|November 6, 1989
Abstract:
Cyclic-disulfide-containing analogues of somatostatin, Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7- Xaa8 [Xaa1 = H or DPhe; Xaa3 = Phe or Tyr; Xaa7 = Cys, Me2Cys or Me2DCys; Xaa8 = OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H-NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.