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Diagnosis of extraesophageal reflux in children with chronic otitis media with effusion using Peptest

Martin Formánek1, Karol Zeleník1, Pavel Komínek1

  • 1Department of Otorhinolaryngology, University Hospital Ostrava, 17, listopadu 1790, 70852 Ostrava, Czech Republic; Faculty of Medicine University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.

International Journal of Pediatric Otorhinolaryngology
|March 5, 2015
PubMed

Insights

Peptest accurately detected pepsin in one-third of middle ear fluid samples from children with otitis media with effusion (OME). This suggests a potential diagnostic role for extraesophageal reflux (EER) in OME patients.

Area of Science:

  • Otolaryngology
  • Pediatric medicine
  • Gastroenterology

Background:

  • Chronic otitis media with effusion (OME) is common in children.
  • Extraesophageal reflux (EER) is a potential contributing factor to OME.
  • Accurate diagnosis of EER in this population remains challenging.

Purpose of the Study:

  • To evaluate the utility of Peptest, a pepsin detection immunoassay, for diagnosing EER in children with OME.
  • To compare Peptest results with previous findings.

Main Methods:

  • A prospective study included children aged 1-7 years diagnosed with OME undergoing myringotomy.
  • Middle ear fluid was collected during myringotomy and analyzed for pepsin using Peptest.
  • Pepsin presence indicated potential EER.

Main Results:

  • Pepsin was detected in 31.8% of middle ear fluid samples (14/44 children).
  • Pepsin was found in 32.2% of middle ear specimens (19/59).
  • Detection rates varied between serous (34.4%) and mucous (22.2%) samples.

Conclusions:

  • Pepsin was detected in approximately one-third of middle ear specimens from OME patients.
  • These findings suggest a potential link between EER and OME severity.
  • Further studies are needed to confirm the role of antireflux therapy in these patients.
Abstract

Keywords:
ChildrenChronic otitis media with effusionDiagnosticExtraesophageal refluxGastroesophageal refluxPepsin

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