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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurological update: emerging issues in gait disorders.

Simon J G Lewis1

  • 1University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia, simonl@med.usyd.edu.au.

Journal of Neurology
|March 5, 2015
PubMed
Summary

Gait disorders are a frequent neurological challenge. This review covers current clinical issues and underlying pathophysiological mechanisms in this expanding field.

Area of Science:

  • Neurology
  • Movement Disorders
  • Clinical Neuroscience

Background:

  • Gait disorders are prevalent and complex issues encountered in neurological practice.
  • Existing literature is growing, addressing both clinical management and fundamental pathophysiology.
  • Understanding the mechanisms behind gait impairment is crucial for effective treatment.

Purpose of the Study:

  • To provide an update on current concepts in gait disorders.
  • To cover a range of clinical issues and pathophysiological mechanisms.
  • To synthesize recent advancements in the field of neurological gait disturbances.

Main Methods:

  • Literature review and synthesis.
  • Analysis of current research trends in gait disorders.

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  • Expert-led conceptual update.
  • Main Results:

    • Identification of key areas of expansion in gait disorder research.
    • Highlighting the interplay between clinical presentation and underlying pathology.
    • Overview of diverse concepts relevant to neurological practice.

    Conclusions:

    • Gait disorders remain a significant focus in neurological research and practice.
    • Continued exploration of pathophysiology is essential for clinical advancements.
    • This update offers insights into contemporary understanding and management strategies.