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A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
MQAPsingle: A quasi single-model approach for estimation of the quality of individual protein structure models
Marcin Pawlowski1, Lukasz Kozlowski2, Andrzej Kloczkowski1,3,4
1Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, 43205.
Abstract:
We present a Model Quality Assessment Program (MQAP), called MQAPsingle, for ranking and assessing the absolute global quality of single protein models. MQAPsingle is quasi single-model MQAP, a method that combines advantages of both "pure" single-model MQAPs and clustering MQAPs. This approach results in higher accuracy compared to the state-of-the-art single-model MQAPs. Notably, the prediction for a given model is the same regardless if this model is submitted to our server alone or together with other models. Proteins 2016; 84:1021-1028. © 2015 Wiley Periodicals, Inc.
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