Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K
Mechanical Systems01:22

Mechanical Systems

873
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically...
873
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.8K
Joints01:26

Joints

36.7K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
36.7K
Neural Regulation01:37

Neural Regulation

45.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.2K
Inflammation01:38

Inflammation

65.8K
Overview
65.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guillain-Barre Syndrome in a Post-COVID-19 Patient who had Rhino-Orbital Mucormycosis.

Neurology India·2024
Same author

3D assessment of ear morphology.

Journal of oral biology and craniofacial research·2023
Same author

Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma.

Microbiology spectrum·2023
Same author

Association of salivary cortisol and psychological burden in patients with oral cancer and oral potentially malignant disorders: A prospective study.

Journal of cancer research and therapeutics·2023
Same author

Dendritic cell-based immunotherapy: a potential player in oral cancer therapeutics.

Immunotherapy·2023
Same author

CHSI costing study-Challenges and solutions for cost data collection in private hospitals in India.

PloS one·2022
Same journal

Salivary metagenomic profiling of <b><i>Neisseria</i></b> , <b><i>Dialister</i></b> , and <b><i>Filifactor</i></b> species in periodontal health and disease using next-generation sequencing.

Journal of oral biology and craniofacial research·2026
Same journal

Retreatability of root canals filled with gutta percha and a novel bioceramic sealer- a scanning electron microscopy study.

Journal of oral biology and craniofacial research·2026
Same journal

Assessment of temporomandibular joint morphological alterations after bilateral sagittal split ramus osteotomy - A systematic review and meta-analysis.

Journal of oral biology and craniofacial research·2026
Same journal

Comparison of red complex bacteria and antimicrobial resistance genes in stage III/IV periodontitis patients with and without type 2 diabetes mellitus: A cross-sectional observational study.

Journal of oral biology and craniofacial research·2026
Same journal

Hallermann-Streiff syndrome: A systematic review of the published literature.

Journal of oral biology and craniofacial research·2026
Same journal

Tissue-engineered approach using autologous fibroblast-seeded volume-stable collagen matrix for managing gingival recession- A randomized controlled clinical trial.

Journal of oral biology and craniofacial research·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

3.7K

TMJ Bioengineering: A review.

Divya Mehrotra1

  • 1Professor, Department of Oral & Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.

Journal of Oral Biology and Craniofacial Research
|March 5, 2015
PubMed
Summary
This summary is machine-generated.

Tissue regeneration research explores scaffolds, growth factors, and stem cells for bone repair. Hydroxyapatite scaffolds show promise for temporomandibular joint (TMJ) disc regeneration, offering a biodegradable solution.

Keywords:
BioengineeringCondyleMandibleRegenerationTMJ

More Related Videos

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

14.7K
Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

15.2K

Related Experiment Videos

Last Updated: Apr 16, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

3.7K
Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

14.7K
Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

15.2K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Craniofacial Surgery

Background:

  • Regenerative strategies using scaffolds, growth factors, and stem cells are crucial for bone repair.
  • PubMed searches reveal limited studies (6/102) on hydroxyapatite scaffolds for condyle regeneration, with 24 focusing on temporomandibular joint (TMJ) scaffolds and 17 on TMJ disc regeneration.
  • The ideal bone construct requires structural replication, functional restoration, safety, reliability, and biodegradability.

Purpose of the Study:

  • To review the current landscape of scaffold-based regeneration for bone repair, particularly focusing on TMJ applications.
  • To highlight the potential of hydroxyapatite scaffolds and mesenchymal stem cells in craniofacial bone regeneration.
  • To discuss the role of scaffolds in supporting cell functions and the impact of gene therapy.

Main Methods:

  • Literature review of PubMed using keywords 'scaffolds' and 'condyle', 'TMJ scaffolds', 'hydroxyapatite scaffolds', and 'TMJ disc regeneration'.
  • Analysis of scaffold materials including natural/synthetic polymers, ceramics, composite materials, and electrospun nanofibers.
  • Discussion of mesenchymal stem cells' role in craniofacial development and tissue engineering.

Main Results:

  • Limited research exists specifically on hydroxyapatite scaffolds for condyle regeneration.
  • Scaffolds serve as essential carriers for mesenchymal stem cells and growth factors, promoting cell adhesion, migration, proliferation, and differentiation.
  • Gene therapy can accelerate effective bone regeneration.

Conclusions:

  • Tissue-engineered bone offers customized shapes and dimensions for craniofacial bone repair.
  • Mesenchymal stem cells are fundamental to forming dental, oral, and craniofacial structures.
  • Advanced scaffold materials and techniques hold significant potential for biological replacement of craniofacial bones.