Oxcarbazepine induced maculopapular rash - a case report

Area of Science:

• Pharmacology
• Dermatology
• Clinical Medicine

Background:

• Oxcarbazepine is a newer anti-epileptic drug known for fewer side effects compared to carbamazepine.
• Drug-induced hypersensitivity reactions, including cutaneous rashes, are a concern with anti-epileptic medications.

Observation:

• A 40-year-old male patient developed an extensive maculopapular rash with intense itching.
• The patient was concurrently taking oxcarbazepine (300mg twice daily) and isoniazid (300mg once daily) as part of anti-tubercular therapy.

Findings:

• The cutaneous rash subsided upon discontinuation of oxcarbazepine, suggesting a causal link.
• This case indicates a potential drug-drug interaction between oxcarbazepine and isoniazid leading to adverse skin reactions.

Implications:

• Clinicians should be aware of the potential for oxcarbazepine-isoniazid drug interactions causing maculopapular rash.
• Concomitant use of oxcarbazepine and isoniazid should be carefully considered and potentially avoided in clinical practice to prevent adverse drug events.