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ALK Positive Anaplastic Large Cell Lymphoma Presenting as Extensive Bone Involvement
Smeeta Gajendra1, Ritesh Sachdev2, Lipika Lipi3
1Attending Consultant, Department of Pathology and Laboratory Medicine, Medanta-The Medicity , Sector -38, Gurgaon, Haryana, India .
Journal of Clinical and Diagnostic Research : JCDR
|March 5, 2015
Summary
Anaplastic large cell lymphoma (ALCL) is rare in bone, but this case shows extensive bone involvement in a child. Histopathology confirmed ALK-positive ALCL, highlighting its potential presentation as a bone tumor.
Area of Science:
- Oncology
- Hematology
- Pediatric Oncology
Background:
- Anaplastic large cell lymphoma (ALCL), specifically ALK-positive ALCL, accounts for about 2% of Non-Hodgkin's lymphomas.
- While ALCL can affect various nodal and extra-nodal sites, primary bone involvement is infrequent.
Observation:
- A 14-year-old female presented with extensive bone lesions.
- Initial clinical diagnosis suggested a bone tumor or small round cell tumor.
Findings:
- Histopathological examination confirmed the diagnosis of ALK-positive ALCL.
- This case demonstrates an unusual presentation of ALK-positive ALCL with significant bone infiltration.
Implications:
- This case underscores the importance of considering ALK-positive ALCL in the differential diagnosis of pediatric bone tumors.
- Recognizing rare presentations of ALCL is crucial for timely and accurate diagnosis in pediatric patients.
- Further research into the mechanisms of bone tropism in ALCL may be warranted.