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Bonebiomarkers in periodontal disease: a review article
V Shankar Ram1, Parthiban2, Uma Sudhakar3
1Reader, Department of Periodontics, Thai Moogambigai Dental College , Chennai, Tamil Nadu, India .
Journal of Clinical and Diagnostic Research : JCDR
|March 5, 2015
Summary
Periodontitis causes bone loss and tooth loss. New bone remodeling biomarkers can help screen, diagnose, and manage this common gum disease.
Area of Science:
- Biochemistry
- Oral Biology
- Periodontology
Background:
- Periodontitis is an inflammatory condition affecting tooth-supporting structures, leading to bone destruction and tooth loss.
- Bone remodeling involves a balance between osteoclast-mediated resorption and osteoblast-mediated formation, crucial for skeletal integrity.
- Imbalances in bone turnover characterize diseases like periodontitis, highlighting the need for monitoring tools.
Purpose of the Study:
- To review recent advancements in bone remodeling biomarkers for periodontal disease.
- To explore the utility of these biomarkers in screening, diagnosis, and management of periodontitis.
Main Methods:
- Literature review of studies on bone remodeling biomarkers in periodontitis.
- Analysis of biomarker roles in bone turnover and disease progression.
Main Results:
- Bone remodeling biomarkers offer insights into the active disease state, progression, and treatment response in periodontitis.
- These markers can reflect the imbalance between bone resorption and formation characteristic of the disease.
Conclusions:
- Bone remodeling biomarkers show promise for improving the clinical management of periodontal diseases.
- Further research into these biomarkers can enhance early detection and personalized treatment strategies.
