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Association between plasma Beta-2 microglobulin level and cardiac performance in patients with chronic kidney disease

Omid Sedighi1, Saeid Abediankenari2, Batoul Omranifar3

  • 1Immunogenetic Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.

Nephro-Urology Monthly
|March 5, 2015
PubMed
Abstract

Insights

Plasma beta-2 microglobulin (B2M) is elevated in chronic kidney disease (CKD) patients. Higher B2M levels correlate with poorer cardiac function and metabolic disturbances in CKD.

Area of Science:

  • Nephrology
  • Biochemistry
  • Cardiology

Background:

  • Beta-2 microglobulin (B2M) is a marker for uremic toxins and dialysis amyloidosis.
  • Limited research exists on B2M's role in chronic kidney disease (CKD).

Purpose of the Study:

  • To investigate the association between plasma B2M levels and metabolic/cardiac factors in CKD patients.

Main Methods:

  • Case-control study involving 86 CKD patients and 78 healthy controls.
  • Measured plasma B2M, inflammatory markers, metabolic factors, and echocardiographic parameters (left ventricular hypertrophy, ejection fraction, LVEDD).

Main Results:

  • CKD patients had significantly higher plasma B2M levels than controls.
  • B2M positively correlated with C-reactive protein, phosphate, left ventricular mass index, and LVEDD.
  • B2M negatively correlated with glomerular filtration rate, albumin, hemoglobin, and ejection fraction.

Conclusions:

  • Plasma B2M levels are inversely associated with glomerular filtration rate and ejection fraction in CKD.
  • Elevated B2M correlates with adverse metabolic and cardiac performance indicators in CKD patients.
Keywords:
Cardiovascular DiseaseChronic Kidney Disease

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