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Identification of a germ line transcript from the unrearranged kappa gene in human B cells
1Department of Biochemistry, University of Iowa, Iowa City 52242.
Abstract:
A novel kappa immunoglobulin-hybridizing mRNA in cell lines derived from human B cells arrested at several stages of development has been identified. Hybridization studies demonstrate that this 1.5-kilobase mRNA species is the spliced product of a precursor germ line transcript initiating upstream of the unrearranged JKappa locus.
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