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Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases

Edmond Y Huang1, Takuya Inoue, Vanessa A Leone

  • 1*Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois; †2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan; ‡Department of Surgery, University of Chicago, Chicago, Illinois; §Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois; ‖Biosciences Division, Argonne National Laboratory, Argonne, Illinois; ¶Department of Ecology and Evolution, University of Chicago, Chicago, Illinois; **Marine Biological Laboratory, Woods Hole, Massachusetts; and ††College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.

Inflammatory Bowel Diseases
|March 5, 2015
PubMed
Summary

Glucocorticoid treatment alters gut microbiota, reducing colonic Muc2 expression. These microbial shifts, particularly in Muc2-knockout mice, influence inflammation, but dexamethasone-treated microbiota can ameliorate inflammatory symptoms.

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