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Updated: Apr 16, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid
Hisae Tateishi-Karimata1, Miki Nakano, Smritimoy Pramanik
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamachi, Kobe 650-0047, Japan.
Abstract:
Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution.
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