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[Enzymatic aspects of severely acute diarrheal disease in infants]

V Lupu, E Damian, D Popa

    Revista De Pediatrie, Obstetrica Si Ginecologie. Pediatria
    |April 1, 1989
    PubMed

    Insights

    Acute dehydration in breast-fed infants can cause hypovolemic shock, affecting the liver. Enzyme levels, indicating liver health, were elevated but normalized within 10 days, suggesting minimal hepatopathy.

    Area of Science:

    • Pediatric emergencies
    • Gastrointestinal disorders
    • Biochemistry

    Context:

    • Acute dehydration from diarrhea is a severe pediatric emergency.
    • Breast-fed infants are particularly vulnerable.
    • The liver is significantly affected due to its metabolic role.

    Purpose:

    • To investigate liver enzyme changes in breast-fed infants with acute dehydration.
    • To assess the severity and reversibility of liver involvement.

    Summary:

    • A study examined liver enzymes (LDH, GDH, GGT, phosphatases) in 27 breast-fed infants with dehydration.
    • Elevated enzyme levels were observed in 40.7-71% of cases upon hospitalization (p < 0.001).
    • Enzyme levels tended to normalize within 10 days, with only 15-12% showing slightly elevated values.

    Impact:

    • Findings suggest minimal, reversible hepatopathy associated with severe dehydration in infants.
    • Highlights the importance of monitoring liver function in pediatric dehydration cases.
    • Provides insights into the clinico-biological evolution of this condition.

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