[Bronchomotor effects of cardioselective beta 1-adrenoblockaders in patients with bronchial asthma]

A study was made of the effect of beta 1-adrenoblockers (metoprolol, atenolol, talinolol) on bronchial patency in patients with concomitant bronchial asthma (BA) under acute drug use and in the course of continuous therapy. Broncho-obstructive complications occurring in part of the patients were not associated with the disease gravity or with the pathogenetic variety of BA. Besides, they were not associated with the drug dose either (use was made of the mean therapeutic dosage range). The rate and the intensity of bronchial patency abnormalities occurring in the course of the continuous treatment with beta 1-adrenoblockers (with metoprolol, in particular) depended on the initial status of the adrenergic regulation of the body. Significant disorders of bronchial patency including clinically marked ones were naturally observed with initially low excretion of cAMP in the morning portion of urine (less than 3 mmole/1).