MRI-based evidence for myocardial involvement in women with hypereosinophilic syndrome

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Tomasz Miszalski-Jamka1, Wojciech Szczeklik, Krzysztof Karwat

  • 1Department of Medicine, Jagiellonian University Medical College ul. Skawinska 8, 31–066 Kraków, Poland; Department of Radiology and Imaging Diagnostics, John Paul II Hospital, Kraków, Poland; Center for Heart Disease, Clinical Military Hospital, Wrocław, Poland. miszalt@mp.pl

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|March 6, 2015
PubMed

Insights

Cardiac abnormalities are common in women with hypereosinophilic syndrome (HES) even with normal initial heart tests. Cardiac magnetic resonance (CMR) detects these issues, which correlate with blood eosinophil counts.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Background:

  • Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent eosinophilia.
  • Cardiac involvement in HES can lead to significant morbidity and mortality.
  • Early detection of cardiac abnormalities is crucial for timely intervention.

Purpose of the Study:

  • To evaluate cardiac abnormalities using cardiac magnetic resonance (CMR) in women with HES.
  • To assess the spectrum of cardiac findings in HES patients with normal electrocardiography (ECG) and transthoracic echocardiography (TTE).
  • To determine the relationship between cardiac abnormalities and blood eosinophil counts.

Main Methods:

  • Ten women with HES of undefined etiology and normal ECG/TTE underwent CMR.
  • Cardiac magnetic resonance imaging was utilized to assess myocardial structure and function.
  • Statistical analysis was performed to correlate findings with blood eosinophil levels.

Main Results:

  • CMR identified cardiac abnormalities in 60% of the women studied.
  • Late gadolinium enhancement (LGE) indicating myocardial scarring was present in 5 patients.
  • CMR evidence of myocardial inflammation was observed in 3 patients, correlating with eosinophil counts.

Conclusions:

  • Women with HES frequently exhibit cardiac abnormalities detectable by CMR, despite normal initial cardiac evaluations.
  • The presence and extent of cardiac abnormalities are associated with the blood eosinophil count.
  • CMR is a valuable tool for diagnosing cardiac involvement in HES.
Abstract

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