[Effect of azelastine on bronchial hyperresponsiveness].

|May 1, 1989

Summary

Azelastine treatment significantly improved bronchial sensitivity (Dmin) in asthmatics over 8 weeks. This asthma medication showed potential benefits by possibly inhibiting leukotriene synthesis and release, key mediators in airway hyperresponsiveness.

Area of Science:

Pharmacology
Respiratory Medicine
Immunology

Context:

Asthma is characterized by bronchial hyperresponsiveness.
Leukotrienes are implicated as key mediators in asthma pathogenesis.
Azelastine is an antihistamine with potential anti-inflammatory properties.

Purpose:

To investigate the effect of azelastine on bronchial responsiveness in patients with asthma.
To assess changes in bronchial sensitivity (Dmin), initial respiratory resistance (RrsC), and bronchial reactivity (SGrs/GrsC) following azelastine treatment.

Summary:

Twenty-five asthmatic patients received 2 mg azelastine twice daily for 8 weeks.
A significant increase in bronchial sensitivity (Dmin) was observed after 8 weeks of treatment.
No significant changes were noted in initial respiratory resistance (RrsC) or bronchial reactivity (SGrs/GrsC).

Impact:

Azelastine may improve asthma control by enhancing bronchial sensitivity.
The observed improvement in Dmin suggests azelastine might inhibit leukotriene synthesis or release.
Further research is warranted to confirm azelastine's role in managing asthma and its underlying mechanisms.

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