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Interactions between CD44 and Hyaluronan in Leukocyte Trafficking
Braedon McDonald1, Paul Kubes2
1Department of Medicine, University of British Columbia , Vancouver, BC , Canada ; Snyder Institute for Chronic Diseases, University of Calgary , Calgary, AB , Canada.
Frontiers in Immunology
|March 6, 2015
Summary
CD44-hyaluronan interactions regulate immune cell trafficking, particularly neutrophils in the liver. Targeting these interactions offers a promising anti-inflammatory treatment strategy for various diseases.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Leukocyte recruitment to inflamed tissues involves adhesion molecule interactions.
- CD44 and hyaluronan (HA) interactions regulate immune cell trafficking.
- Neutrophil recruitment in the liver microcirculation is critical for innate immunity and inflammatory diseases.
Purpose of the Study:
- To summarize the biology of CD44-HA interactions in cell trafficking.
- To focus on neutrophil recruitment in the liver microcirculation.
- To explore the role of CD44-HA interactions in innate immunity and inflammatory disease pathogenesis.
Main Methods:
- Review of existing literature on CD44-HA interactions.
- Analysis of molecular mechanisms regulating neutrophil CD44 and endothelial HA adhesion.
- Inclusion of evidence on serum-derived hyaluronan-associated protein as a co-factor.
Main Results:
- CD44-HA interactions are crucial for neutrophil recruitment.
- Serum-derived hyaluronan-associated protein enhances HA binding to CD44 under flow.
- CD44-HA-mediated neutrophil recruitment contributes to host defense and disease pathogenesis.
Conclusions:
- CD44-HA interactions play a significant role in immune cell trafficking and inflammation.
- Targeting CD44-HA interactions is a potential anti-inflammatory therapeutic strategy.
- Blockade of neutrophil recruitment via CD44-HA interactions shows promise in animal models of inflammatory diseases.
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