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Updated: Apr 16, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Are submicroscopic chromosomal inversions predisposing factors for the t(9;22)(q34;q11.2) translocation in chronic
Juan Ramón González García1, Martín Daniel Domínguez Cruz2, César Borjas Gutiérrez2
1División de Genética, CIBO-Instituto Mexicano del Seguro Social, Sierra Mojada # 800, Colonia Independencia, CP 44340 Guadalajara, Jalisco México.
Abstract:
A complex chromosomal rearrangement observed in a patient with chronic myeloid leukemia was explained as the consequence of a multistep process. The explanation involved an initial t(9;22) translocation with breakpoints distant from the BCR and ABL1 genes followed by genomic deletions that produced the BCR-ABL1 hybrid gene. We present an alternative model that fits the origin of the patient's rearrangement better. The present model links submicroscopic inversions with the occurrence of the t(9;22) translocation and opens a new approach on the research on the disease.
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