Cuscuta reflexa and Carthamus Oxyacantha: potent sources of alternative and complimentary drug
Muhammad Asam Raza1, Fareeha Mukhtar1, Muhammad Danish1
1Centre of Natural Products, Department of Chemistry, University of Gujrat, Gujrat, Pakistan.
Abstract:
The present study was designed to evaluate the biological potential of Cuscuta reflexa and Carthamus oxyacantha. The ethanolic crude extract (C. reflexa; 9.1% and C. oxyacantha; 10.4%) was partitioned with different solvents at pH 3.0, 9.0 and 7.0. Phytochemical study showed that n-hexane fractions were rich source of terpenoids and ethyl acetate fractions were phenolic in nature while chloroform fractions contained alkaloidal skeleton. Total phenols were calculated with FC method and ranged 3.5 to 71.4 mg GAE/100 g DW. Antioxidant (DPPH & FRAP), enzyme inhibition potential (Protease & AChE) and antimicrobial activities were examined by the standard protocols. It was observed that about all extracts exhibited significant DPPH activity range (IC50 09 ± 0.5 to 62 ± 1.2 μg/ml). The DPPH active extracts/fractions also showed remarkable reducing potential. A strong correlation has been found between phenolics and antioxidant activities. Antimicrobial assay that was performed against four microbes and results revealed that FMC-6 and FMP-8 were active against all the tested microbes, while FMP-2 was inactive. Eight extracts/fractions of these plants expressed more than 50% inhibition of the targeted enzymes.
More Related Videos
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
03:40Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
Related Concept Videos
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Cholinergic Antagonists: Pharmacokinetics
Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
