Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recent highlights in motor recovery and rehabilitation research after stroke.

Journal of physiotherapy·2026

Same author

Effects of social support interventions on social, physical and mental health outcomes: a scoping review.

BMJ public health·2026

Same author

Hallucinogen-Psychosis Associations Are Confounded by Baseline Psychiatric History.

The Journal of clinical psychiatry·2026

Same author

Causal involvement of two parietal regions in the integration of visuospatial attention and semantic memory.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026

Same author

Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Assessing movement quality in individuals with Duchenne muscular dystrophy utilizing accelerometry: Comparisons with healthy controls.

PLOS digital health·2026

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Common behavioral clusters and subcortical anatomy in stroke.

Maurizio Corbetta¹, Lenny Ramsey², Alicia Callejas³

¹Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, Saint Louis, MO, 63110, USA; Radiology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, Saint Louis, MO, 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, Saint Louis, MO, 63110, USA; Department of Bioengineering, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, Saint Louis, MO, 63110, USA.

|March 6, 2015

Summary

Stroke primarily causes subcortical damage, impacting multiple brain functions through white matter tract disconnection. Lesion location significantly influences motor and language deficits, emphasizing the need for advanced models of white matter damage on cognition.

More Related Videos

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Related Experiment Videos

Last Updated: Apr 16, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Area of Science:

Neuroscience
Neurology
Cognitive Science

Background:

Traditional views link stroke to specific neurological syndromes from localized brain damage.
The utility of syndrome-based descriptions for characterizing diverse stroke-related behavioral deficits remains unclear.

Purpose of the Study:

To investigate if a syndrome-based approach effectively characterizes behavioral deficits in a large cohort of first-time stroke patients.
To explore the relationship between lesion anatomy, particularly white matter tract integrity, and behavioral impairments post-stroke.

Main Methods:

Prospective study of first-time stroke patients with heterogeneous lesions (1-2 weeks post-stroke).
Behavioral assessments across multiple domains combined with structural MRI and a probabilistic white matter atlas.
Multivariate analyses to quantify variance in behavioral deficits explained by structural damage.

Main Results:

A few clusters of multi-functional behavioral deficits explained neurological impairment.
Stroke topography was predominantly subcortical, with white matter tract disconnection significantly contributing to deficits.
Lesion locus explained more variance in motor and language deficits compared to memory or attention.

Conclusions:

Stroke-induced behavioral deficits are influenced by subcortical damage and white matter tract disconnection.
Current models may need refinement to fully account for the impact of white matter damage on cognitive functions.
Further research is needed to develop better models of white matter damage and its effects on cognition.