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Updated: Apr 16, 2026

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
Published on: October 25, 2019
Recognition and Impact of Host-derived Molecules on Bacterial Cell-to-cell Signalling Pathways
Alina-Maria Holban, Mariana Carmen Chifiriuc, Veronica Lazar1
1University of Bucharest, Faculty of Biology, Department of Botanic-Microbiology, Ale. Portocalelor 1-3, 60101, Bucharest, Romania. carmen_balotescu@yahoo.com.
Abstract:
Microbe-host signalling is now a well accepted concept and an intensively studied research field. Although some of the observed bacterial phenotypes are attributed to host-recognition and inter-kingdom signalling, most of them are not relying on a proved molecular mechanism. Recent progress revealed some recognition and signalling pathways for host molecules in bacterial cells, which try to explain their modulatory effect on growth and virulence. Since the current knowledge on the field is poor and debatable, the purpose of this paper is to review and discuss the research performed in order to elucidate the ways by which microbial cells recognize and decode the host molecule signals.
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