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Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink

Rosa Parisi1, Martin K Rutter2, Mark Lunt3

  • 1Centre for Pharmacoepidemiology & Drug Safety, Manchester Pharmacy School, University of Manchester, Manchester, UK.

The Journal of Investigative Dermatology
|March 6, 2015
PubMed

Insights

Psoriasis is not linked to major cardiovascular events in the short-to-medium term. This study found no significant association after accounting for other cardiovascular risk factors.

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • Psoriasis is a chronic inflammatory disease with potential systemic implications.
  • The relationship between psoriasis and major adverse cardiovascular events (MACE) requires further clarification.

Purpose of the Study:

  • To investigate the association between psoriasis and the risk of major cardiovascular events.
  • To determine if severe psoriasis increases cardiovascular risk.

Main Methods:

  • A cohort study included 48,523 patients with psoriasis and 208,187 controls.
  • Median follow-up was 5.2 years, with major cardiovascular events meticulously recorded.
  • Multivariable analysis adjusted for numerous cardiovascular disease risk factors.

Main Results:

  • The age- and gender-adjusted hazard ratios (HRs) for major cardiovascular events in psoriasis patients were 1.10 and 1.40 for severe psoriasis.
  • Fully adjusted HRs were attenuated to 1.02 for psoriasis and 1.28 for severe psoriasis.
  • Significant risk factors included inflammatory arthritis, diabetes, chronic kidney disease, hypertension, transient ischemic attack, atrial fibrillation, valvular heart disease, thromboembolism, congestive heart failure, depression, current smoking, age, and male gender.

Conclusions:

  • Psoriasis and severe psoriasis were not associated with an increased short-to-medium term risk of major cardiovascular events.
  • The association is attenuated after adjusting for established cardiovascular disease risk factors.
  • Further research may explore long-term cardiovascular outcomes in psoriasis patients.

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