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Updated: Apr 16, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or
Chan Ho Kim1, Seung Jun Kim1, Mi Jung Lee2
1Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea; Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Korea.
Introduction:
Mean platelet volume (MPV) is suggested as an index of inflammation, disease activity, and anti-inflammatory treatment efficacy in chronic inflammatory disorders; however, the effect of MPV on sepsis mortality remains unclear. Therefore, we investigated whether the change in MPV between hospital admission and 72 hours (ΔMPV72h-adm) predicts 28-day mortality in severe sepsis and/or septic shock.
Methods:
We prospectively enrolled 345 patients admitted to the emergency department (ED) who received standardized resuscitation (early goal-directed therapy) for severe sepsis and/or septic shock between November 2007 and December 2011. Changes in platelet indices, including ΔMPV72h-adm, were compared between survivors and non-survivors by linear mixed model analysis. The prognostic value of ΔMPV72h-adm for 28-day mortality was ascertained by Cox proportional hazards model analysis.
Results:
Thirty-five (10.1%) patients died within 28 days after ED admission. MPV increased significantly during the first 72 hours in non-survivors (P = 0.001) and survivors (P < 0.001); however, the rate of MPV increase was significantly higher in non-survivors (P = 0.003). Nonetheless, the difference in the platelet decline rate over the first 72 hours did not differ significantly between groups (P = 0.360). In multivariate analysis, ΔMPV72h-adm was an independent predictor of 28-day mortality, after adjusting for plausible confounders (hazard ratio, 1.44; 95% confidence interval, 1.01-2.06; P = 0.044).
Conclusions:
An increase in MPV during the first 72 hours of hospitalization is an independent risk factor for adverse clinical outcomes. Therefore, continuous monitoring of MPV may be useful to stratify mortality risk in patients with severe sepsis and/or septic shock.
Insights
An increasing mean platelet volume (MPV) in the first 72 hours of hospitalization independently predicts mortality in severe sepsis and septic shock patients. Monitoring MPV changes can help stratify risk for adverse outcomes.
Area of Science:
- Critical Care Medicine
- Hematology
- Inflammation Research
Background:
- Mean platelet volume (MPV) is an indicator of inflammation and disease activity.
- Its role in predicting sepsis mortality is not well-established.
- Investigating MPV changes in severe sepsis is crucial.
Purpose of the Study:
- To determine if the change in MPV from hospital admission to 72 hours (ΔMPV72h-adm) predicts 28-day mortality in severe sepsis and/or septic shock.
- To assess the prognostic value of MPV dynamics in critically ill patients.
Main Methods:
- Prospective enrollment of 345 severe sepsis/septic shock patients receiving standardized resuscitation.
- Comparison of changes in platelet indices, including ΔMPV72h-adm, between survivors and non-survivors.
- Prognostic value assessed using Cox proportional hazards models.
Main Results:
- A higher rate of MPV increase was observed in non-survivors compared to survivors within the first 72 hours.
- ΔMPV72h-adm was identified as an independent predictor of 28-day mortality (HR, 1.44; 95% CI, 1.01-2.06; P = 0.044).
- Platelet decline rates did not significantly differ between groups.
Conclusions:
- An increase in MPV during the initial 72 hours of hospitalization is an independent risk factor for adverse outcomes in sepsis.
- Continuous MPV monitoring may aid in stratifying mortality risk for patients with severe sepsis and septic shock.
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