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Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
L Costas1, C Infante-Rivard2, J-P Zock3
11] Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, 08908 Barcelona, Spain [2] Department of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] CIBER Epidemiologia y Salud Pública (CIBERESP), Madrid, Spain.
Background:
Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.
Methods:
We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.
Results:
Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.
Conclusions:
Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.
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