Age-specific risk of breast cancer in women with neurofibromatosis type 1
Related Experiment Video
Updated: Apr 16, 2026
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
1Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
Background:
Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might have implications for screening programmes. Our aim was to calculate this risk.
Methods:
An all-England linked data set of hospital admissions and deaths was analysed to determine age-specific rates of breast cancer in women with NF1 and controls.
Results:
The age-specific excess risk of breast cancer, comparing the NF1 cohort with the control cohort, was elevated 6.5-fold (95% confidence interval 2.6-13.5) in women aged 30-39 years. There was a 4.4 (2.5-7.0) times higher risk among women aged 40-49.
Conclusions:
Women with NF1 develop breast cancer at younger ages than the general population.
More Related Videos
Related Concept Videos
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
02:59Cancer Prevention
Some...
01:12Relative Risk