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The effect of cinnamaldehyde on the growth and the morphology of Candida albicans.

Medical molecular morphology·2013
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Effect of cinnamaldehyde on hyphal growth of C. albicans under various treatment conditions.

Medical mycology journal·2012
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Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis.

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Therapeutic effects on murine oral candidiasis by oral administration of cassia (Cinnamomum cassia) preparation.

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·2010
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Protection of oral or intestinal candidiasis in mice by oral or intragastric administration of herbal food, clove (Syzygium aromaticum).

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·2005

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[Oral health care by utilizing food function].

Yuuki Taguchi1

  • 1Research and Product Development Division, S & B Foods Inc.

Medical Mycology Journal
|March 7, 2015
PubMed
Summary

Spices like clove and cassia inhibit Candida albicans growth, offering potential natural treatments for oral candidiasis. Cinnamaldehyde showed enhanced efficacy with prolonged use and combination therapy.

Area of Science:

  • Mycology
  • Natural Products Chemistry
  • Oral Health Research

Background:

  • Candida albicans is a fungus normally present in oral flora.
  • Overgrowth causes oral candidiasis, leading to inflammation and reduced quality of life, especially in the elderly.
  • Developing natural therapeutic tools is crucial for managing oral diseases.

Purpose of the Study:

  • To investigate the effects of spices and herbs on Candida albicans.
  • To explore the potential of natural compounds as therapeutic agents against oral candidiasis.
  • To present findings on daily spice and herb use for oral health improvement.

Main Methods:

  • In vitro testing of spice and herb extracts against Candida albicans mycelial growth.
  • In vivo studies using a murine model of oral candidiasis.

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  • Evaluation of cinnamaldehyde activity, including prolonged treatment and combination with methylcellulose.

    • Main Results:

    • Clove (Syzygium aromaticum) and cassia (Cinnamomum aromaticum) demonstrated inhibitory activity against Candida mycelial growth.
    • Cinnamaldehyde showed dose-dependent and time-dependent inhibitory effects.
    • Combination therapy with cinnamaldehyde and methylcellulose potentiated therapeutic effects in the murine model.

    Conclusions:

    • Spices, particularly clove and cassia, possess significant antifungal properties against Candida albicans.
    • Cinnamaldehyde is a key active compound with therapeutic potential for oral candidiasis.
    • Natural compounds from spices and herbs offer promising avenues for preventing and treating oral fungal infections.