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Prenatal sex determination by DNA amplification from maternal peripheral blood
Y M Lo1, P Patel, J S Wainscoat
1University of Oxford Clinical School.
Lancet (London, England)
|December 9, 1989
Abstract:
The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.