Related Experiment Video
Updated: Apr 16, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
The role of the insulin-like growth factor-1 system in breast cancer
Panagiotis F Christopoulos1, Pavlos Msaouel2, Michael Koutsilieris3
1Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Goudi, Athens, Greece. panutsoschr@hotmail.com.
Abstract:
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
Mitogens and the Cell Cycle
Insulin: The Receptor and Signaling Pathways
PI3K/mTOR/AKT Signaling Pathway
Regulation of Angiogenesis and Blood Supply

