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Chemoprevention in Barrett's oesophagus

Anushka Baruah1, Navtej S Buttar1

  • 1Mayo Clinic College of Medicine, Department of Gastroenterology and Hepatology, Rochester, MN, USA.

Best Practice & Research. Clinical Gastroenterology
|March 7, 2015
PubMed

Insights

Barrett

Area of Science:

  • Gastroenterology and Oncology
  • Molecular Biology

Background:

  • Rising rates of oesophageal adenocarcinoma and low survival necessitate new prevention methods.
  • Barrett's oesophagus is a precursor to oesophageal adenocarcinoma.

Purpose of the Study:

  • To identify novel chemoprevention targets for Barrett's oesophagus.
  • To review epidemiological and molecular data for target identification.
  • To discuss current chemoprevention trials.

Main Methods:

  • Review of epidemiological associations.
  • Analysis of molecular mechanisms in Barrett's mucosa.
  • Literature review of chemoprevention trials.

Main Results:

  • Identification of potential pro-oncogenic pathways for targeted intervention.
  • Summary of evidence linking specific factors to neoplastic transformation.
  • Overview of the status and findings of recent chemoprevention studies.

Conclusions:

  • Targeting specific molecular pathways in Barrett's mucosa offers a promising strategy for oesophageal adenocarcinoma prevention.
  • Further research and clinical trials are needed to validate these chemoprevention targets.
Keywords:
Barrett's oesophagus(BO)Chemo-preventive agentsOesophageal adenocarcinoma(OAC)Surrogate endpoint markers(SEBs)

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