Related Experiment Video
Updated: Apr 16, 2026

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography
Published on: November 29, 2017
Reducing pain from heel lances in neonates following education on oral sucrose
1Department of Pharmacy, Winthrop-University Hospital, 259 1st Street, Mineola, NY, 11501, USA, mshen@winthrop.org.
Insights
Implementing sucrose and non-pharmacological methods significantly reduced pain during heel lances in neonates. Education improved the consistent use of sucrose, a safe and effective pain management strategy in the neonatal intensive care unit (NICU).
Area of Science:
- Neonatal care
- Pain management
- Quality improvement
Background:
- Heel lances are frequent, painful procedures in the neonatal intensive care unit (NICU).
- Inconsistent application of pain relief methods was observed during these procedures.
Purpose of the Study:
- To enhance pain management for heel lance-induced pain in the NICU.
- To implement and evaluate a three-phase quality improvement project.
Main Methods:
- A quality improvement project was conducted in a 27-bed NICU.
- Baseline pain scores (N-PASS) were recorded before, during, and after heel lances in 25 neonates (Phase 1).
- Nurses and physicians received education on sucrose and non-pharmacological pain management techniques, followed by post-education evaluation (Phase 3) with another 25 neonates.
Main Results:
- Sucrose use increased by 84% post-education.
- Neonatal pain scores during heel lances decreased by 11.2% after the educational intervention.
- No adverse effects were reported with sucrose use; neonates receiving sucrose had lower pain scores.
Conclusions:
- Healthcare providers were aware of sucrose but underutilized it for neonatal pain.
- Education effectively promoted the adoption of sucrose use for heel lance pain management.
- Sucrose is a safe and effective intervention for reducing procedural pain in neonates.
Background:
Heel lances are common painful procedures performed in the neonatal intensive care unit (NICU). Upon observation, pain relieving methods were not consistently applied during such procedures in our institution.
Objective:
The objective of this three-phase quality improvement project was to improve pain management for heel lance-induced pain in the NICU.
Setting:
This study took place in a 27-bed NICU in a level IV perinatal regional center at a 591 bed university affiliated teaching hospital in New York, United States.
Method:
Study Phase 1, involving 25 neonates, documented baseline pain management strategies and pain scores, which were measured before, during, and after heel lancing using the Neonatal Pain Agitation and Sedation Scale (N-PASS). In Study Phase 2, nurses and physicians were educated on the use of sucrose and non-pharmacological measures to prevent and manage heel lance-induced pain. Study Phase 3 (Post education evaluation), had the same procedure as Study Phase 1, and involved another host of 25 neonates.
Main Outcome Measure:
Pain scores were compared in groups of neonates in Phase 1 (before education) and Phase 3 (after education) before, during and after heel lancing. Other outcome measures included quantifying the use of sucrose and documenting any adverse effects.
Results:
We found an 84 % increase in the use of sucrose post-education (Phase 3), and most importantly, an 11.2 % reduction in pain scores from heel lances in neonates. Four neonates who did not receive sucrose in Phase 3 had higher pain scores during heel lancing than those who did (3.5 and 2.38, respectively). There were no adverse effects reported with sucrose.
Conclusion:
Health care providers were aware of sucrose but were not using this treatment modality, despite its availability on nursing units. Education was effective in the adoption of sucrose use, leading to a reduction in pain from heel lances in neonates.
Related Concept Videos
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drug Delivery: Enteral Route
Local Anesthetics: Differential Sensitivity of Nerve Fibers

