Related Experiment Video
Updated: Aug 4, 2026
Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
Published on: February 1, 2012
Resting-state functional connectivity of antero-medial prefrontal cortex sub-regions in major depression and
Helen Sawaya1, Kevin Johnson1, Matthew Schmidt1
1American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); Washington State University, Department of Integrative Physiology and Neuroscience Washington (Dr Panksepp).
Background:
Major depressive disorder has been associated with abnormal resting-state functional connectivity (FC), especially in cognitive processing and emotional regulation networks. Although studies have found abnormal FC in regions of the default mode network (DMN), no study has investigated the FC of specific regions within the anterior DMN based on cytoarchitectonic subdivisions of the antero-medial pre-frontal cortex (PFC). Studies from different areas in the field have shown regions within the anterior DMN to be involved in emotional intelligence. Although abnormalities in this region have been observed in depression, the relationship between the ventromedial PFC (vmPFC) function and emotional intelligence has yet to be investigated in depressed individuals.
Methods:
Twenty-one medication-free, non-treatment resistant, depressed patients and 21 healthy controls underwent a resting state functional magnetic resonance imaging session. The participants also completed an ability-based measure of emotional intelligence: the Mayer-Salovey-Caruso Emotional Intelligence Test. FC maps of Brodmann areas (BA) 25, 10 m, 10r, and 10p were created and compared between the two groups.
Results:
Mixed-effects analyses showed that the more anterior seeds encompassed larger areas of the DMN. Compared to healthy controls, depressed patients had significantly lower connectivity between BA10p and the right insula and between BA25 and the perigenual anterior cingulate cortex. Exploratory analyses showed an association between vmPFC connectivity and emotional intelligence.
Conclusions:
These results suggest that individuals with depression have reduced FC between antero-medial PFC regions and regions involved in emotional regulation compared to control subjects. Moreover, vmPFC functional connectivity appears linked to emotional intelligence.
More Related Videos
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
