Related Experiment Video
Updated: Apr 16, 2026
11:32
Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels
Published on: February 22, 2019
12.0K
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics
Lolly Pattnaik1, Laxmikanta Acharya2
1Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
Life Sciences
|March 7, 2015
Summary
Vernal keratoconjunctivitis (VKC), an allergic eye condition, is increasingly understood to involve both IgE and non-IgE mechanisms. Ongoing research promises new diagnostic tools for early detection and treatment of this seasonal eye allergy.
Area of Science:
- Ophthalmology
- Allergology
- Immunology
Background:
- Allergic conjunctivitis encompasses various conditions, including seasonal and perennial forms.
- Vernal keratoconjunctivitis (VKC) is a specific allergic eye disorder often linked to seasonal allergens.
Purpose of the Study:
- To review the epidemiology, clinical features, and ocular associations of VKC.
- To explore current treatment options and histopathological understanding of VKC.
- To systematically analyze proteomics studies and evolving immunological mechanisms of VKC.
Main Methods:
- Systematic review of existing literature on VKC.
- Analysis of epidemiological data and clinical presentations.
- Review of histopathological findings and proteomics research.
Main Results:
- VKC involves complex immunological mechanisms beyond solely IgE-mediated responses.
- Understanding of VKC's histopathology has progressed significantly.
- Proteomics studies offer insights into disease mechanisms.
Conclusions:
- The understanding of VKC pathogenesis has evolved from IgE-only to include non-IgE mechanisms.
- Advances in research are paving the way for novel diagnostic strategies for VKC.
- Future developments aim for earlier detection and improved therapeutic outcomes for allergic eye diseases like VKC.
Related Concept Videos
01:22Microbiome of the Eye
60
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
60
01:33Proteomics
10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.2K
01:26Nephrotic Syndrome II : Assessment and Medical Management
377
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
377