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Related Concept Videos

Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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mGluRs head to toe in pain.

Benedict J Kolber1

  • 1Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, USA.

Progress in Molecular Biology and Translational Science
|March 7, 2015
PubMed
Summary

Metabotropic glutamate receptors (mGluRs) modulate pain signaling across the nervous system. Targeting specific mGluR subtypes offers potential for novel pain treatments.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Metabotropic glutamate receptors (mGluRs) are crucial in pain signaling.
  • Their diverse roles in the peripheral and central nervous system are key to understanding pain modulation.

Purpose of the Study:

  • To explore the neuraxis using mGluRs as a model system.
  • To detail the structure, function, and pain-modulating roles of various mGluR subtypes.

Main Methods:

  • Review of mGluR structure and function.
  • Analysis of mGluR involvement at different levels of the pain neuraxis, from peripheral terminals to higher brain centers.
  • Examination of emerging mGluR-targeted pain therapies.

Main Results:

  • mGluRs can either enhance or reduce pain, contingent on subtype and location.
Keywords:
G-protein-coupled receptorGlutamateMetabotropic glutamate receptorPainmGluR

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  • Different mGluR subtypes play distinct roles in processing noxious stimuli and the cognitive/emotional aspects of pain.

    • Conclusions:

    • mGluRs represent a versatile target for pain management.
    • Understanding mGluR activity across the neuraxis is vital for developing effective pain therapeutics.