Stress and chronic pelvic pain
Angela N Pierce1, Julie A Christianson1
1Department of Anatomy and Cell Biology, School of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Progress in Molecular Biology and Translational Science
|March 7, 2015
Summary
Chronic pelvic pain syndromes, including irritable bowel syndrome and interstitial cystitis, are diagnosed by exclusion. Early life stress increases pelvic pain likelihood, while acute stress worsens symptoms.
Area of Science:
- Urology
- Gastroenterology
- Pain Medicine
- Psychosomatic Medicine
Background:
- Chronic pelvic pain is a leading cause for medical visits among patients with functional syndromes like irritable bowel syndrome (IBS), interstitial cystitis/painful bladder syndrome (IC/PBS), vulvodynia, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
- These conditions often lack identifiable pathology or etiology, complicating diagnosis and treatment.
- Dysfunction in the immune, central nervous, and peripheral nervous systems is implicated.
Purpose of the Study:
- To describe individual chronic pelvic pain syndromes.
- To elucidate the influence of stress on the diagnosis and symptom severity of these conditions.
Main Methods:
- Review of existing literature on chronic pelvic pain syndromes.
- Analysis of the relationship between stress exposure (early life and acute) and pelvic pain.
Main Results:
- Chronic pelvic pain syndromes are frequently diagnosed by exclusion due to overlapping symptoms and lack of clear pathology.
- Early life stress is associated with an increased likelihood of developing pelvic pain later in life.
- Acute stress can exacerbate symptom severity in patients with these conditions.
Conclusions:
- Stress significantly impacts the development and severity of chronic pelvic pain syndromes.
- Understanding the role of stress is crucial for effective diagnosis and treatment strategies for patients with functional pelvic pain disorders.
Keywords:
Corticotropin-releasing factorGlucocorticoidHypothalamic–pituitary–adrenal axisMast cellNeonatal maternal separationMore Related Videos
Related Concept Videos
Disorders of the Female Reproductive System
4.9K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.9K
Chronic Pancreatitis I: Introduction
933
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
933
Chronic Bowel Disorders: Introduction
951
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
951
Muscles of the Pelvic Floor and Perineum
6.5K
The muscles of the pelvic floor and perineum are crucial for supporting the pelvic organs, controlling continence, and aiding in sexual function, childbirth, and core stability. They are typically divided into the superficial perineal layer and the deep pelvic floor layer.
Perineal Layer
The perineum is a diamond-shaped area below the pelvic diaphragm, divided into an anterior urogenital triangle that contains the external genitals and a posterior anal triangle housing the anus. The urogenital...
Perineal Layer
The perineum is a diamond-shaped area below the pelvic diaphragm, divided into an anterior urogenital triangle that contains the external genitals and a posterior anal triangle housing the anus. The urogenital...
6.5K
Psychoneuroimmunology: Cardiovascular Disease
720
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
720
Stress and Mental Health
1.5K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.5K


