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Related Experiment Videos

Rats self-administer sufentanil in aerosol form.

A B Jaffe1, L G Sharpe, J H Jaffe

  • 1Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.

Psychopharmacology
|January 1, 1989
PubMed
Summary

Researchers developed a novel animal model for studying inhaled psychoactive drugs. Rats self-administered sufentanil vapor, demonstrating its reinforcing properties via the pulmonary route.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Animal Models

Background:

  • Developing animal models for nonvolatile psychoactive drug self-administration is challenging.
  • Inhaled drug delivery offers a potential route for rapid systemic absorption.

Purpose of the Study:

  • To establish an animal model for self-administration of inhaled nonvolatile psychoactive drugs.
  • To examine the reinforcing properties and dose-dependency of sufentanil citrate delivered via aerosol.

Main Methods:

  • An ultrasonic nebulizer generated sufentanil citrate aerosol for rat delivery.
  • Rats responded on a fixed-ratio (FR 5) schedule for drug vapor access.
  • Acquisition, dose-dependency, and antagonist effects (naloxone) were assessed.

Main Results:

  • Rats rapidly acquired responding for sufentanil vapor compared to water vapor.
  • Sufentanil self-administration was dose-dependent (25-75 µg/ml).
  • Naloxone significantly reduced sufentanil-maintained responding.

Conclusions:

  • Aerosolized drug delivery via ultrasonic nebulization is effective for creating an animal model of self-administration for nonvolatile drugs.
  • This model demonstrates the reinforcing properties of inhaled sufentanil citrate.
  • The pulmonary route offers a viable method for studying drug reinforcement in animal models.

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