Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major

Rebecca MacGregor Legge1, Shahbaz Sendi1, James H Cole1

  • 1Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; Andrew Simmons, PhD, Department of Neuroimaging, Institute of Psychiatry, National Institute of Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR Biomedical Research Centre for Mental Health at South London and Department of Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute of Psychiatry, King's College London, and School of Psychology, University of East London, London, UK.

Abstract

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
125
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.6K