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Updated: Aug 18, 2026
Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Quantitation by computerized visual image analysis of gastric mucosal lesions induced in mice and rats by
1Department of Biomedical Sciences, McMaster University, Health Sciences Faculty, Hamilton, Ontario, Canada.
Abstract:
A method is described for the quantative determination of gastric mucosal lesions induced by non-steroidal anti-inflammatory drugs in mice and rats. The area and number of gastric lesions present in formalin-fixed, glycerol-cleared mucosa is determined by computerized visual image analysis using instrumentation as described. The method is also applied to the determination of the protective effects of anti-ulcer agents (e.g. prostaglandin E2, pirenzepine). Thus this method affords unambiguous sensitive and determination of the percentage area of the mucosa damaged and the number of the lesions.
