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Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India

Divya Chauhan1, Kiran Mokta1, Anil Kanga1

  • 1Department of Microbiology, Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India.

Annals of Indian Academy of Neurology
|March 7, 2015
PubMed

Insights

Group B Streptococcus (GBS) meningitis is a significant cause of acute bacterial meningitis in Indian children over one month old. Further research is needed to understand the full scope of this serious infection.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Group B Streptococcus (GBS) is a common cause of meningitis in neonates.
  • Data on GBS meningitis in older infants and children, particularly in India, is limited.

Purpose of the Study:

  • To investigate the clinical and laboratory features of GBS meningitis in children aged 1 to 59 months.
  • To determine the outcomes and complications associated with GBS meningitis in this age group.

Main Methods:

  • Cerebrospinal fluid (CSF) samples from 250 children with suspected acute bacterial meningitis (ABM) were analyzed.
  • Diagnostic methods included cell count, biochemical tests, culture, latex particle agglutination (LPA), and PCR.
  • Patients were monitored for complications and followed up for six months post-discharge.

Main Results:

  • GBS was diagnosed in 40 children (16% of suspected ABM cases), with 75% aged over three months.
  • The median hospital stay was 7 days; 5% experienced coma, and one patient (2.5%) died.
  • Half of the patients (50%) achieved a complete recovery.

Conclusions:

  • GBS is an important cause of ABM in Indian children beyond the neonatal period.
  • Further studies are recommended to fully understand the burden of GBS meningitis in India.
Abstract

Keywords:
Acute bacterial meningitisgroup B streptococcuslatex particle agglutinationneonatal mortality

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