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Related Experiment Video

Updated: Apr 16, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Bone muscle interactions and vitamin D.

Jenny E Gunton¹, Christian M Girgis², Paul A Baldock³

¹Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Garvan Institute of Medical Research, Sydney, NSW, Australia; Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, NSW, Australia; Westmead Millennium Institute, Westmead Hospital, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.

|March 10, 2015

Summary

This summary is machine-generated.

Vitamin D plays a crucial role in both bone and skeletal muscle health. Emerging research highlights its direct, integrated regulation of these tissues, suggesting potential therapeutic applications for musculoskeletal conditions.

Keywords:

Bone Cross-talk Muscle Osteoporosis Sarcopenia Vitamin D

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Area of Science:

Endocrinology and Metabolism
Musculoskeletal Physiology
Cell Biology

Background:

Vitamin D is traditionally known for bone and mineral homeostasis.
Emerging evidence reveals significant roles in skeletal muscle function.
Severe deficiency or receptor mutations impact both muscle and bone, indicating coordinated effects.

Purpose of the Study:

To review the integrated roles of vitamin D in regulating bone and skeletal muscle.
To explore the mechanistic pathways involved in vitamin D's effects on musculoskeletal tissues.
To position the vitamin D pathway as a therapeutic target for musculoskeletal diseases.

Main Methods:

Review of existing scientific literature on vitamin D, bone, and muscle.
Analysis of mechanistic studies on calcium handling, differentiation, and hormonal modulation.
Synthesis of evidence on the cross-talk between bone and muscle mediated by vitamin D.

Main Results:

Vitamin D directly influences calcium handling, differentiation, and development in both muscle and bone.
Vitamin D modulates hormones derived from muscle and bone, facilitating inter-tissue communication.
Evidence supports a coordinated regulatory role of vitamin D across the musculoskeletal system.

Conclusions:

Vitamin D acts as a key regulator of integrated musculoskeletal physiology.
The vitamin D pathway presents a promising therapeutic target for various musculoskeletal disorders.
Understanding vitamin D's cross-talk mechanisms is vital for treating bone and muscle diseases.