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Published on: February 15, 2019
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T-style keratoprosthesis based on surface-modified poly (2-hydroxyethyl methacrylate) hydrogel for cornea repairs
Jun Xiang1, Jianguo Sun2, Jiaxu Hong1
1Department of Ophthalmology, Eye & ENT Hospital, Shanghai Medical College, Fudan University, China; Key Laboratory of Myopia, Ministry of Health, Fudan University, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, China.
Summary
A novel T-style artificial cornea (keratoprosthesis) was developed to address donor cornea shortages. Surface modifications promote tissue integration and prevent complications, offering a promising alternative for corneal blindness.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Tissue Engineering
Background:
- Corneal diseases are a leading cause of blindness globally.
- A significant shortage of donor corneas limits the effectiveness of traditional keratoplasty.
- Artificial cornea (keratoprosthesis) development is crucial for treating corneal blindness.
Purpose of the Study:
- To present a novel T-style keratoprosthesis design and preparation methods.
- To evaluate the biointegration and efficacy of the artificial cornea for treating corneal opacity and limbal stem cell deficiency.
Main Methods:
- Fabrication of a T-style keratoprosthesis using poly(2-hydroxyethyl methacrylate) hydrogel.
- Surface modification of the porous skirt (hyaluronic acid, cationized gelatin) and optical column (poly(ethylene glycol)).
- Characterization using spectrophotometry, electron microscopy, FTIR, and XPS.
- In vivo implantation experiments to assess biocompatibility and integration.
Main Results:
- The T-style keratoprosthesis demonstrated favorable physical and chemical properties.
- Surface modifications promoted corneal tissue adhesion to the skirt and resisted cell adhesion on the optical column.
- In vivo studies indicated successful biointegration and potential for long-term stability.
Conclusions:
- The novel T-style keratoprosthesis offers mechanical stability and effective biointegration.
- Surface modifications successfully prevent retroprosthetic membrane formation and promote corneal tissue bonding.
- This artificial cornea is a promising alternative for patients with severe corneal conditions unresponsive to traditional treatments.
