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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats

Dan Zhang¹, Chao Huang², Wenyu Xin³

¹Institute of Materia Medica, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100050, China; Pharmacy Department, China-Japan Friendship Hospital, Beijing 100029, China.

Journal of Pharmaceutical and Biomedical Analysis

|March 10, 2015

Abstract:

Methyl salicylate-2-O-β-d-lactoside (MSL) is a natural salicylate derivative from the traditional Chinese medicine of Gaultheria yunnanensis (Franch.) Rehder (G. yunnanensis). As a non-steroidal anti-inflammatory drug (NSAID), MSL exerts a significant anti-arthritis effect but hardly has any gastrointestinal toxicity. In this paper, the pharmacokinetics, distribution, excretion and identification of MSL and its metabolites are described following rat oral and intravenous administration. The biological samples were quantified by UPLC-MS/MS and the metabolites in urine and feces were identified by using Q-TOF-MS. These results will support future investigations leading to clinical development of this drug.

Keywords:

Metabolites Methylsalicylate-2-O-beta-d-lactoside Pharmacokinetic Tandem mass spectrometry

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