Related Experiment Video
Updated: Apr 16, 2026
09:37
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
3.1K
[Basal cell carcinoma with matrical differentiation]
Gabrielle Goldman-Lévy1, Eric Frouin1, Isabelle Soubeyran2
1Laboratoire d'anatomie et cytologie pathologiques, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
Annales De Pathologie
|March 10, 2015
Summary
Basal cell carcinoma with matrical differentiation is a rare tumor. This study investigates the role of beta-catenin in its development, offering insights into its histogenesis.
Area of Science:
- Dermatopathology
- Oncology
- Molecular Biology
Background:
- Basal cell carcinoma (BCC) is the most common human cancer.
- Basal cell carcinoma with matrical differentiation (BCC-MD) is an exceptionally rare variant.
- The physiopathogenesis of BCC-MD is not fully understood.
Observation:
- This study presents a novel case of BCC-MD.
- Immunohistochemical and molecular analyses of beta-catenin were performed.
- The tumor exhibited basaloid lobules differentiating towards pilar matrix cells.
Findings:
- Beta-catenin is implicated in the physiopathogenesis of matrical tumors.
- This analysis provides further evidence for beta-catenin's role in BCC-MD.
- The study aims to elucidate the histogenesis of this rare BCC variant.
Implications:
- Understanding beta-catenin's role may lead to targeted therapies for BCC-MD.
- This research contributes to the knowledge of rare skin cancer variants.
- Further investigation into beta-catenin signaling pathways is warranted.
Related Concept Videos
01:30Skin Cancer
6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
00:57Cellular Differentiation
6.5K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
6.5K
01:03Basal Lamina are the Specialized Form of ECM
4.2K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
4.2K
01:06Multipotency and Niche of Bulge Stem Cell
4.4K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.4K
01:12Renewal of Skin Epidermal Stem Cells
3.3K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.3K
02:30Metastasis
7.0K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
7.0K