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Delayed repeat enemas are safe and cost-effective in the management of pediatric intussusception
Timothy B Lautz1, Cary W Thurm2, David H Rothstein3
1Division of Pediatric Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Insights
Delayed repeat enemas for pediatric ileocolic intussusception improve nonoperative reduction success. This approach reduces bowel resection rates, hospital stays, and costs compared to immediate surgery.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Medical Interventions
Background:
- Ileocolic intussusception is a common surgical emergency in children.
- Initial enema reduction is attempted but may fail.
- Management strategies for failed reduction include immediate surgery or delayed repeat enema.
Purpose of the Study:
- To compare outcomes of delayed repeat enema (DRE) versus immediate surgery (IS).
- To evaluate the efficacy of DRE in children with ileocolic intussusception who fail initial enema reduction.
Main Methods:
- Retrospective cohort study using the Pediatric Health Information System (PHIS) database (2008-2012).
- Included children under 6 years old with ileocolic intussusception.
- Outcomes analyzed: bowel resection, length of stay (LOS), and adjusted hospital costs (AHC).
Main Results:
- Delayed repeat enema (DRE) was used in 26.3% of patients after failed initial reduction, while immediate surgery (IS) was performed in 73.7%.
- Bowel resection rates were significantly lower with DRE (11.8%) compared to IS (26.4%) (p<0.001).
- DRE was associated with shorter LOS (3.2 days vs 4.4 days) and lower AHC ($9205 vs $14,422) compared to IS.
Conclusions:
- Delayed repeat enemas are effective in increasing nonoperative reduction success for ileocolic intussusception.
- DRE significantly decreases the need for bowel resection.
- This strategy leads to reduced hospital length of stay and healthcare costs.
Background/Purpose:
The purpose of the study is to compare outcomes between delayed repeat enema (DRE) and immediate surgery (IS) in children with ileocolic intussusception who fail initial enema reduction.
Methods:
Retrospective cohort study of children <6 years-of-age from 2008 to 2012 in the Pediatric Health Information System (PHIS) database. Outcomes measured were bowel resection, length of stay (LOS), and adjusted hospital costs (AHC).
Results:
4980 of 6889 (72.3%) children with intussusception were discharged without operation following a single successful enema. 1407 of 1909 (73.7%) remaining patients underwent IS while 502 (26.3%) had a DRE. Bowel resection was required in 372 of 1407 (26.4%) patients in IS group compared to 59 of 502 (11.8%) in the DRE group (p<0.001). The number of patients needed to treat by DRE to prevent a bowel resection was 7. In multivariable analysis, the IS patients had a 2.5 times greater likelihood of undergoing bowel resection than the DRE patients (adjusted odds ratio [OR] 2.50, 95% confidence interval [CI] 1.83-3.41, p<0.001). The DRE group had a mean LOS of 3.2 days (95% CI 2.9-3.6) and mean AHC of $9205 (95% CI $7673-$10,735). The IS group had a longer LOS (4.4days, 95% CI 4.0-4.8, p≤0.001) and higher AHC ($14,422, 95% CI $12,631-$16,214, p<0.001).
Conclusion:
Delayed repeat enemas for ileocolic intussusception increase the success of nonoperative reduction, decrease the rate of bowel resection and reduce mean hospital length of stay and costs.
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