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Role of Mucin 1 and Glycodelin A in recurrent implantation failure
Ercan Bastu1, Mehmet F Mutlu2, Cenk Yasa1
1Department of Obstetrics and Gynecology, Istanbul University School of Medicine, Istanbul, Turkey.
Objective:
To evaluate and compare the levels of Mucin 1 (MUC-1) and Glycodelin A (GdA) in precisely timed endometrial biopsies and blood samples taken from women with recurrent implantation failure, and women with proven fertility, in a control group.
Design:
Molecular studies in human blood and tissue.
Setting:
University hospital.
Patient(S):
Women with recurrent implantation failure and women with proven fertility.
Intervention(S):
Primary endometrial cells and blood samples during the implantation "window" (between day 7 and day 9 after the surge in luteinizing hormone).
Main Outcome Measure(S):
Expression of MUC-1 and GdA in the human endometrium and in blood during the implantation window were analyzed by enzyme-linked immunosorbent assay. Additionally, MUC-1 and GdA levels in tissue were analyzed by western blot during the same period.
Result(S):
Both blood and tissue measurements of MUC-1 and GdA were significantly lower in women with recurrent implantation failure than in fertile women during the implantation window. In addition, we found a highly significant correlation between blood vs. tissue measurements of both MUC-1 and GdA.
Conclusion(S):
The present study reveals that blood and tissue levels of MUC-1 and GdA are much lower in women with RIF, compared with those in fertile women. Receptivity can be evaluated with noninvasive blood sampling, rather than more-invasive endometrium sampling, as the blood and tissue measurements of MUC-1 and GdA are correlated.
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