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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Cyclic sulfoxides-garlicnins K1, K2, and H1-extracted from Allium sativum
Toshihiro Nohara1, Yukio Fujiwara, Yusuke Komota
1Faculty of Pharmaceutical Sciences, Sojo University.
Abstract:
Newly identified cyclic sulfoxides-garlicnins K1 (1), K2 (2), and H1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.
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